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Can I Microdose While Pregnant or Breastfeeding?

Updated: Jun 14, 2021

This question has been presented a few times and it seems timely to spend some time addressing this topic. As of now, no significant research has been done on the effects of using psilocybin or LSD during pregnancy in any doses. A very small statistically insignificant research involving pregnant mothers who took LSD reported adverse effects on a specific chromosome but much more comprehensive research is needed to better understand the effects of LSD on pregnancy. To date, there have been no studies focused on pregnancy and psilocybin. Due to a lack of evidence suggesting safety, my recommendation to pregnant women is to avoid ALL substances in all dosages to ensure the safety of the fetus and the mother.

As in the case of pregnancy, there is currently no reliable research to assess any adverse effects of microdosing while breastfeeding. With that said, there are anecdotal reports of microdosing mothers finding relief from post-partum depression, and the medicinal use of psychedelic plants while breastfeeding is common practice amongst some indigenous cultures. Since research is lacking in this area, I do not make a recommendation on the topic one way or another and suggest each mother make their own informed decision by weighing the benefits of the practice with the potential adverse effects.

Here are a few key points to keep in mind when weighing options:

  • Psilocybin is cleared in the body within 15 hours with no traces found in the bloodstream at the 24 hours marker. Larger than standard doses will take longer to metabolize.

  • LSD is cleared in the body within 16 hours with no traces found in the bloodstream at the 24 hours marker. Larger than standard doses will take longer to metabolize.

  • There are no scientific research studies on the safety of these substances while breastfeeding.

  • Many indigenous women take part in ritual ceremonies involving psychedelic plants while breastfeeding but no long-term research data exists to assess any potential adverse effects.

  • Do NOT take any amount of psychedelics while taking antidepressants.

  • Always consult your physician before taking any new medicines of any kind.


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The perspectives and recommendations on this website are not made by a medical professional and should not be considered medical advice. Readers are encouraged to consult their physician before taking any supplements or substances. 


While we believe that psychedelic medicines must be decriminalized, psychedelic substances are still considered  "Schedule I" substances in the US and continue to be subject to strong enforcement across nearly all states. The reader is responsible for checking their local rules and regulations and making informed decisions with all risk considerations. Microdose Guru does not endorse or accept liability for its readers' personal choices.  

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