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Psilocybin and Treatment-Resistant Depression

Treatment-Resistant Depression (TRD) is one of the most debilitating chronic mental health conditions characterized as a depression that lasts for many years and does not respond to a variety of conventional treatments and is accompanied by suicidal ideation. Some estimates suggest that as many as 60% of individuals with depression qualify as TRD patients.

While there are currently no definitively effective TRD treatments available, psilocybin therapy seems to offer a glimmer of hope for the patients. The Green Prophet publication recently published an article outlining the promising effects of psilocybin-therapy in the early studies associated with TRD.

"The use of psychedelics in healthcare is not new—historical evidence of many cultures used ‘magic mushrooms’ to achieve a state of enlightenment. To unlock the brain, creativity, and existential thoughts is part of the psychedelic ‘trip.’ And now, western medicine is taking a look at the potential to use it to penetrate treatment-resistant depression and provide relief."

"... Johns Hopkins University released an exciting study. Published in JAMA Psychiatry, the clinical trial revealed that 71% of patients experienced a clinically significant response to psilocybin therapies. And 54% of participants met the clinical criteria for “remission of depression.”"


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The perspectives and recommendations on this website are not made by a medical professional and should not be considered medical advice. Readers are encouraged to consult their physician before taking any supplements or substances. 


While we believe that psychedelic medicines must be decriminalized, psychedelic substances are still considered  "Schedule I" substances in the US and continue to be subject to strong enforcement across nearly all states. The reader is responsible for checking their local rules and regulations and making informed decisions with all risk considerations. Microdose Guru does not endorse or accept liability for its readers' personal choices.  

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