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Can a Single Dose of Psilocybin Change The Brain?

With the revival of psychedelic research for mental health in the past few years, there has been no shortage of published findings demonstrating the positive and promising possibilities of psychedelic therapies in the treatment of a variety of challenges including Treatment-Resistant Depression (TRD), Anxiety, Addiction, and PTSD to name a few. The bulk of these studies have involved multiple facilitated sessions with large doses, as well as microdosing over many weeks demonstrating verifiable changes in the brain, but what are the effects of a single dose?

PsyPost recently highlighted details of research by a Danish team that found a measurable boost in the neural connections of the brain following a single dose of psilocybin.

“We find that a single dose of psilocybin increases the presynaptic marker SV2A already after one day and that it remains higher seven days after,” the researchers said, adding that the “increased levels of SV2A after intervention with a psychedelic drug adds to the scientific evidence that psychedelics enhance neuroplasticity, which may explain the mechanism of action of its antidepressant properties.”


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The perspectives and recommendations on this website are not made by a medical professional and should not be considered medical advice. Readers are encouraged to consult their physician before taking any supplements or substances. 


While we believe that psychedelic medicines must be decriminalized, psychedelic substances are still considered  "Schedule I" substances in the US and continue to be subject to strong enforcement across nearly all states. The reader is responsible for checking their local rules and regulations and making informed decisions with all risk considerations. Microdose Guru does not endorse or accept liability for its readers' personal choices.  

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