Wellbutrin works differently from SSRIs, so it likely will not dampen a microdose the way other antidepressants can. But that is not the same as "safe to combine." The real questions are seizure threshold and overstimulation, not serotonin syndrome. Here is what the pharmacology shows and where the honest gaps are.

No, there's no evidence microdosing psilocybin weakens hormonal birth control — the drugs that do work through a liver enzyme, psilocin doesn't touch. The more useful question is the reverse: how your hormones and your contraceptive change the way a microdose feels. Here's what the research actually shows.

A comprehensive overview of risk factors and pharmaceutical contraindications when combined with psychedelics.