Updated: Nov 19, 2021
While strict schedule and dosage compliance is recommended for microdosing, from time to time, microdosing practitioners might want to take a larger dose. There are no studies done that combine the effects of microdosing and macrodosing so no clinically verified knowledge exists in this space. The recommendation below is my personal approach and opinion.
Although following a microdosing schedule is important for cultivating lasting results, an occasional large dose can be accommodated without impacting the benefits of the microdosing practice if the following conditions are met:
The larger dose substance is identical to the microdosing substance
The larger dose is taken during the "on-cycle" and not during the days/weeks that are meant to be "off days"
The dosage is within the standard recommended range and not considered an extra-large dose
The source and quality of the substance has been verified for safety
The individual has the capacity, time, and resources to properly integrate the experience
The individual doesn't have any medical or psychiatric conditions counter-indicative to large doses of psychedelics
The individual is not taking any prescription medications with negative counter-interactions with the substance
The individual either has extensive personal experience with large doses or is guided and supported by a trained professional
Taking larger doses does not deliver more impactful results and should not be approached as such. If you are curious about working with larger doses for therapeutic effects, it is best to find a trained and experienced practitioner to ensure safety and efficacy.