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Can I Macrodose while Microdosing?

Updated: Nov 19, 2021

While strict schedule and dosage compliance is recommended for microdosing, from time to time, microdosing practitioners might want to take a larger dose. There are no studies done that combine the effects of microdosing and macrodosing so no clinically verified knowledge exists in this space. The recommendation below is my personal approach and opinion.

Although following a microdosing schedule is important for cultivating lasting results, an occasional large dose can be accommodated without impacting the benefits of the microdosing practice if the following conditions are met:

  • The larger dose substance is identical to the microdosing substance

  • The larger dose is taken during the "on-cycle" and not during the days/weeks that are meant to be "off days"

  • The dosage is within the standard recommended range and not considered an extra-large dose

  • The source and quality of the substance has been verified for safety

  • The dose is taken in a conscious and mindful manner

  • The individual has the capacity, time, and resources to properly integrate the experience

  • The individual doesn't have any medical or psychiatric conditions counter-indicative to large doses of psychedelics

  • The individual is not taking any prescription medications with negative counter-interactions with the substance

  • The individual either has extensive personal experience with large doses or is guided and supported by a trained professional

Taking larger doses does not deliver more impactful results and should not be approached as such. If you are curious about working with larger doses for therapeutic effects, it is best to find a trained and experienced practitioner to ensure safety and efficacy.


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The perspectives and recommendations on this website are not made by a medical professional and should not be considered medical advice. Readers are encouraged to consult their physician before taking any supplements or substances. 


While we believe that psychedelic medicines must be decriminalized, psychedelic substances are still considered  "Schedule I" substances in the US and continue to be subject to strong enforcement across nearly all states. The reader is responsible for checking their local rules and regulations and making informed decisions with all risk considerations. Microdose Guru does not endorse or accept liability for its readers' personal choices.  

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