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Can I Use Other Substances While Microdosing?

Updated: Jun 14, 2021

The question of the effects of using other substances while microdosing is a common one. While has been no research on or reports of serious counter-interactions between microdosing psychedelics and consuming other substances, as a microdosing guide I encourage my clients to strictly avoid some substances while eliminate or reduce the use of others. Here is why! Microdosing is an invitation to subtlety and mindfulness; it is an opportunity to slow down and examine our habits and behaviors. Very often my clients report experiencing spontaneous awareness about their actions, lifestyle, thoughts, and emotions. While the exact mechanism of these experiences isn't fully known, there is ample evidence suggesting a surge in novel neural activity in the brain capable of facilitating new insights, awareness, and even lasting behavioral change. This particular experience is one of the most profound and sought-after benefits of microdosing especially for those seeking relief from symptoms of long-term depression, anxiety, OCD, and addictions. Consuming other altering substances interferes with the dynamic and unique mechanisms of the microdose functions in the brain hindering its effects and benefits. This is true during active hours and days of microdosing, as well as the off days and hours in between. With that said, while I strictly advise against combining any substances with microdosing during active microdosing hours, the occasional use of small amounts of cannabis and alcohol outside of microdosing hours is generally low-impact for most individuals and does not hinder the expression of the benefits. I do advise against the use of other substances, especially amphetamines (cocaine, meth, Adderal) and large amounts of alcohol and cannabis during a microdosing cycle as they tend to interfere with the very essence of the microdose practice and the uniquely dynamic state of a microdosing brain. One important detail to keep in mind is that each individual has different body chemistry and responds differently to combining substances. It is important to note that if you are currently taking any prescription medications, you should not alter or stop your dose, or begin a microdose practice before consulting your physician.


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The perspectives and recommendations on this website are not made by a medical professional and should not be considered medical advice. Readers are encouraged to consult their physician before taking any supplements or substances. 


While we believe that psychedelic medicines must be decriminalized, psychedelic substances are still considered  "Schedule I" substances in the US and continue to be subject to strong enforcement across nearly all states. The reader is responsible for checking their local rules and regulations and making informed decisions with all risk considerations. Microdose Guru does not endorse or accept liability for its readers' personal choices.  

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