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Can Microdosing Change Stable Personality Traits?

Psychedelic medicine users have long reported experiencing profound shifts in their values, perception, and sense of self; many claiming to have experienced shifts in their personality.

A recent small study involving 90 participants published in the Journal of Psychedelic Studies explored the relationship between microdosing, personality change, and emotional awareness and found that the consumption of sub-perceptual doses of psychedelic drugs might have an impact on otherwise stable personality traits.

Among the study’s findings:

  • A short course of microdosing led to increased conscientiousness.

  • Neuroticism decreased in a sample of more experienced microdosers. Prior microdosing was found to have a negative correlation with neuroticism and a positive correlation with extraversion.

  • A negative association between emotional insight and neuroticism.

While this study was small-scale and not as precise as a controlled experiment with predetermined dosing amounts, fixed schedules, and a placebo-control condition, these findings do open the door to further research to build on the exploratory findings of this study in an effort to expand our understanding of the impact of microdosing on shifts in personality traits.


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The perspectives and recommendations on this website are not made by a medical professional and should not be considered medical advice. Readers are encouraged to consult their physician before taking any supplements or substances. 


While we believe that psychedelic medicines must be decriminalized, psychedelic substances are still considered  "Schedule I" substances in the US and continue to be subject to strong enforcement across nearly all states. The reader is responsible for checking their local rules and regulations and making informed decisions with all risk considerations. Microdose Guru does not endorse or accept liability for its readers' personal choices.  

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