top of page

Can Psilocybin Be As Effective As Lexapro In Treating Depression?

Updated: Jan 9, 2023

In the first study of its kind, a phase 2 double-blind study recently compared the efficacy of psilocybin mushrooms with that of the commonly prescribed SSRI Escitalopram (aka Lexapro) in the treatment of complex depression. The results of the study published in the New England Journal of Medicine suggest that psilocybin appears to be as effective or perhaps even more effective than Lexapro in alleviating symptoms of depression.

"The six-week study involved 59 adults, 40 percent of whom had been taking depression medication but weaned off of the drugs in order to participate in the study. Thirty of the participants received two 25mg doses of psilocybin three weeks apart, as well as six weeks of a daily placebo pill.

The remaining 29 were also given a sub-hallucinogenic microdose of psilocybin during two visits and a daily dose of escitalopram, the active ingredient in the antidepressant Lexapro. All psilocybin doses were given in a clinician’s office and participants were monitored while under the influence of the medicine.

At the end of the six-week study, researchers used four measures to determine whether participants’ symptoms had improved. One of the measures showed psilocybin to be just as effective at treating depression symptoms as escitalopram. The other three showed psilocybin to be superior at treating symptoms."


mindful microdosing.jpeg

Mindful Microdosing Course

A 6-Week Self-Guided Journey To Build, Evolve & Deepen Your Mindful Microdosing Practice 



The perspectives and recommendations on this website are not made by a medical professional and should not be considered medical advice. Readers are encouraged to consult their physician before taking any supplements or substances. 


While we believe that psychedelic medicines must be decriminalized, psychedelic substances are still considered  "Schedule I" substances in the US and continue to be subject to strong enforcement across nearly all states. The reader is responsible for checking their local rules and regulations and making informed decisions with all risk considerations. Microdose Guru does accept liability for its readers' personal choices. We are a strictly educational platform. 

bottom of page