One of the most common mistakes in microdosing practice is not taking off days, off weeks, and extended off cycles from the practice. Psychedelic substances are powerful compounds with a profound impact on brain and nervous system functions. They bind to various receptors in our brain and often have healing, regulatory, and boosting effects on the production of various neurochemicals. While in the short term this is highly desirable, in the long term they can be ineffective and in some instances even harmful. Our brains are highly adaptable structures highly sensitive to chemical changes, this means that while psychedelic substances can promote and regulate certain neurotransmitters, with regular use they have the potential to disrupt the natural production of these compounds. This is why it is critical to have off day, off weeks, and off cycles carefully incorporated into the microdosing protocol to ensure maximum benefits and safety. In my practice, I recommend a 4 1/2 month protocol cycle (which includes off days and off weeks) followed by many months of no microdosing. I have found that most individuals who seek creativity boosting effects generally do not need to complete more than one cycle a year while individuals microdosing for anxiety, depression, and trauma tend to benefit from two cycles a year. I have also noticed that occasional booster doses in between cycles are a great "pick-me-up" for anyone moving through a particularly challenging week or seeking an extra boost of creativity for a specific purpose.
